Everything should be as simple as
possible, but not simpler. Albert Einstein
Biotechnology research seeks to develop applications of molecular
biology. Many sources use analogies to recipe books or blueprints to
explain the role of DNA and genes in molecular biology. Ultimately,
these analogies obscure the importance of topics such as regulation
of gene expression, which is fundamentally important to appreciate
in order to understand molecular biology. When applying one's
knowledge of biotechnology fundamentals, most metaphors fail.
It is only by understanding molecular biology and biotechnology
applications that one can appreciate the applications and limitations
of techniques used in molecular biology.
This chapter presents a brief, analogy-free, introduction
to molecular biology. Subsequent chapters describe the tools,
techniques, and applications of biotechnology and provide greater details on the potential and
limitations of molecular biology.
The Central Dogma of Molecular
Biology
The central dogma of molecular biology describes the flow of
information
in living organisms. In order to understand the basis of most
biotechnology
applications, it is necessary to first understand the central dogma.
The Central Dogma of Molecular
Biology
Genetic information is contained in DNA and leads to the formation of
proteins through an intermediate called mRNA.